{
  "version": "two_RNA_update",
  "natural_sources": [
    "GSE281449",
    "GSE130973"
  ],
  "primary_reference": "RNA_FDR05: two-study signed Stouffer + BH; 0 selected / 8519 tested",
  "exploratory_reference": "R68: each RNA P<=0.10 and abs(log2FC)>=0.25, concordant; 68 genes",
  "model_thresholds": "unchanged FDR05 and FDR05_abs05; n1 descriptive_abs05",
  "universe": "shared tested natural and model genes; no new gene aliases",
  "scope": "20 retained model/treatment comparisons; KD/KO excluded; interventions not ranked with induction",
  "modules": "same members in two natural RNA studies and model, >=3 genes; original source designs; two-source signed Stouffer",
  "interpretation": "Exploratory concordance, not independently validated aging signature"
}